Proteomics in multiple sclerosis: the perspective of the clinician

D Sandi, Z Kokas, T Biernacki, K Bencsik… - International Journal of …, 2022 - mdpi.com
Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS) that affects approximately 2.8 million people worldwide. In …

ctDNA-based liquid biopsy of cerebrospinal fluid in brain cancer

L Escudero, F Martínez-Ricarte, J Seoane - Cancers, 2021 - mdpi.com
Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …

Characterization and diagnosis spectrum of patients with cerebrospinal fluid pleocytosis

S Dyckhoff-Shen, JP Bewersdorf, NC Teske, S Völk… - Infection, 2024 - Springer
Purpose There is an overlap in the cerebrospinal fluid (CSF) characteristics of patients
presenting with different etiologies of CSF pleocytosis. Here, we characterized patients with …

Analysing cerebrospinal fluid with explainable deep learning: From diagnostics to insights

L Schweizer, P Seegerer, H Kim… - Neuropathology and …, 2023 - Wiley Online Library
Aim Analysis of cerebrospinal fluid (CSF) is essential for diagnostic workup of patients with
neurological diseases and includes differential cell typing. The current gold standard is …

The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease

S Strader, AB West - Biochemical Society Transactions, 2023 - portlandpress.com
The accumulation of aggregated α-synuclein in susceptible neurons in the brain, together
with robust activation of nearby myeloid cells, are pathological hallmarks of Parkinson's …

Dynamic cerebrospinal fluid analyses of severe pseudorabies encephalitis

L Zheng, X Liu, D Yuan, R Li, J Lu, X Li… - Transboundary and …, 2019 - Wiley Online Library
We reported a severe human pseudorabies encephalitis case and described a dynamic
clinical manifestation with cerebrospinal fluid analyses and cytological and serological …

New frontiers in diagnosis and therapy of circulating tumor markers in cerebrospinal fluid in vitro and in vivo

OA Sindeeva, RA Verkhovskii, M Sarimollaoglu… - Cells, 2019 - mdpi.com
One of the greatest challenges in neuro-oncology is diagnosis and therapy (theranostics) of
leptomeningeal metastasis (LM), brain metastasis (BM) and brain tumors (BT), which are …

[PDF][PDF] Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid

C Douville, S Curtis, M Summers, TD Azad… - Cell Reports …, 2023 - cell.com
It is often challenging to distinguish cancerous from non-cancerous lesions in the brain
using conventional diagnostic approaches. We introduce an analytic technique called Real …

Flow cytometric detection of malignant blasts in cerebrospinal fluid: a biomarker of central nervous system involvement in childhood acute lymphoblastic leukemia

M Thastrup, HV Marquart, K Schmiegelow - Biomolecules, 2022 - mdpi.com
Despite the excellent prognosis for children and adolescents with acute lymphoblastic
lymphoma (ALL), the involvement of the central nervous system (CNS) represents a major …

Characterization of the blood and cerebrospinal fluid microbiome in children with bacterial meningitis and its potential correlation with inflammation

H Liao, Y Zhang, W Guo, X Wang, H Wang, H Ye… - Msystems, 2021 - Am Soc Microbiol
Bacterial meningitis shows a higher incidence in children than adults, but signs may be
scarce. Although some pathogenic microorganisms of meningitis from cerebrospinal fluid …