Optimizing precision in cellular clocks through self-regulated accumulation of molecules

S Rezaee, C Nieto, A Singh - 2023 27th International …, 2023 - ieeexplore.ieee.org
The timing of cellular events is often determined by the instant when the level of a chemical
species crosses a threshold from an initial value of zero. To attenuate the inherent random …

Mixed-feedback architectures for precise event timing through stochastic accumulation of biomolecules

S Rezaee, C Nieto, A Singh - bioRxiv, 2023 - biorxiv.org
The timing of biochemical events is often determined by the accumulation of a protein or
chemical species to a critical threshold level. In a stochastic model, we define event timing …

[PDF][PDF] Precision of Biomolecular Timekeeping Through Regulated Degradation

S Rezaee, C Nieto, A Singh - 2023 - osf.io
The timing of biochemical processes within cells is inextricably linked to the level of key
regulatory proteins crossing critical threshold levels. Recent research has primarily focused …