Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Glioblastoma (GBM) is an adult's most aggressive brain tumor. The advances in molecular
pathology and cell signaling pathways have deepened researchers' understanding of …

Antisense oligonucleotides (ASOs) dosed into cerebrospinal fluid (CSF) distribute broadly
throughout the central nervous system (CNS). By modulating RNA, they hold the promise of …

Brain metastasis (BrM) is a common malignancy, predominantly originating from lung,
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …

Glioblastoma (GBM) is a hypoxic and" immune-cold" tumor containing rich stromal signaling
molecules and cell populations, such as proteases and immunosuppressive tumor …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

The intricate vascular system of the kidneys supports body fluid and organ homeostasis.
However, little is known about how vascular architecture is established during kidney …

Abstract TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that regulates
gene expression, and its malfunction in neurons has been causally associated with multiple …

Many neurological conditions conceal specific anatomical patterns. Their study contributes
to the understanding of disease biology and to tailored diagnostics and therapy …