Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged
mitochondria and the production of reactive oxygen species (ROS). The relationship …

Mitochondria are known to generate approximately 90% of cellular reactive oxygen species
(ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production …

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized
by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical
challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent …

Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …

Ischemic stroke is one of the leading causes of death and also a major cause of adult
disability worldwide. Revascularization via reperfusion therapy is currently a standard …

Chronic kidney disease (CKD) is a major public health concern, underscoring a need to
identify pathogenic mechanisms and potential therapeutic targets. Reactive oxygen species …