Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and
environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet …

Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …

Women gradually lose bone from the age of~ 35 years, but around menopause, the rate of
bone loss escalates due to increasing bone resorption and decreasing bone formation …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …

Osteoporosis and osteopenia impact more than 54 million Americans, resulting in significant
morbidity and mortality. Alterations in bone remodeling are the hallmarks for osteoporosis …

Background Diabetes-related osteoporosis (DOP) is a chronic disease caused by the high
glucose environment that induces a metabolic disorder of osteocytes and osteoblast …

Bone tissue undergoes constant remodeling and healing when fracture happens, in order to
ensure its structural integrity. In order to better understand open biological and clinical …

It is well established that multinucleation is central for osteoclastic bone resorption.
However, our knowledge on the mechanisms regulating how many nuclei an osteoclast will …