The bone marrow side of axial spondyloarthritis

D Mauro, S Gandolfo, E Tirri, G Schett… - Nature Reviews …, 2023 - nature.com
Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …

Why inhibition of IL-23 lacked efficacy in ankylosing spondylitis

D McGonagle, A Watad, K Sharif… - Frontiers in …, 2021 - frontiersin.org
The term spondyloarthritis pertains to both axial and peripheral arthritis including ankylosing
spondylitis (AS) and psoriatic arthritis (PsA), which is strongly linked to psoriasis and also …

Genetically proxied IL‐13 inhibition is associated with risk of psoriatic disease: Mendelian randomization study

SS Zhao, K Hyrich, Z Yiu, A Barton… - Arthritis & …, 2024 - Wiley Online Library
Objective Inhibitors of the IL‐13 pathway, such as dupilumab, are licensed for atopic
dermatitis and asthma. Adverse events resembling psoriatic disease after dupilumab …

From bed to bench and back: TNF-α, IL-23/IL-17A, and JAK-dependent inflammation in the pathogenesis of psoriatic synovitis

E Silvagni, S Missiroli, M Perrone… - Frontiers in …, 2021 - frontiersin.org
Psoriatic arthritis (PsA) is a chronic inflammatory immune-mediated disease with a
burdensome impact on quality of life and substantial healthcare costs. To date …

The potential role of genetics, environmental factors, and gut dysbiosis in the aberrant non-coding RNA expression to mediate inflammation and osteoclastogenic …

HT Liao, CY Tsai, CC Lai, SC Hsieh, YS Sun… - Frontiers in cell and …, 2022 - frontiersin.org
Ankylosing spondylitis (AS) or radiographic axial spondyloarthritis is a chronic immune-
mediated rheumatic disorder characterized by the inflammation in the axial skeleton …

Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review

F Orsini, C Crotti, G Cincinelli, R Di Taranto, A Amati… - Biology, 2023 - mdpi.com
Simple Summary Chronic inflammatory arthritis, such as rheumatoid arthritis (RA) and
spondyloarthritis (SpA), often have a significant impact on bone tissue, where bone is not …

Characterization of a Musculoskeletal Syndrome of Enthesitis and Arthritis in Patients With Atopic Dermatitis Treated With Dupilumab, an Interleukin‐4/13 Inhibitor

CD Hughes, J Nathan, L Mathew, AE Pink… - Arthritis & …, 2023 - Wiley Online Library
Objective To characterize the presentation and outcomes of patients with atopic dermatitis
(AD) who developed musculoskeletal symptoms after treatment with dupilumab, a human …

Osteoimmunology of Spondyloarthritis

A Fassio, F Atzeni, M Rossini, V D'Amico… - International Journal of …, 2023 - mdpi.com
The mechanisms underlying the development of bone damage in the context of
spondyloarthritis (SpA) are not completely understood. To date, a considerable amount of …

[HTML][HTML] Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

J Krstić, S Mojsilović, SS Mojsilović… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
Bone regeneration is a tightly regulated process that ensures proper repair and functionality
after injury. The delicate balance between bone formation and resorption is governed by …

[HTML][HTML] Network pharmacology analysis and animal experiment validation of neuroinflammation inhibition by total ginsenoside in treating CSM

Z Li, Y Dai, Z Wu, G Li, P Pu, C Hu, L Zhou, K Zhu… - Phytomedicine, 2024 - Elsevier
Background Cervical spondylotic myelopathy (CSM) is a degenerative pathology that affects
both upper and lower extremity mobility and sensory function, causing significant pressure …