Antimicrobial resistance poses a growing threat to public health and the provision of health
care. Its surveillance should provide up-to-date and relevant information to monitor the …

The gut microbiome is now considered an organ unto itself and plays an important role in
health maintenance and recovery from critical illness. The commensal organisms …

Background The prevalence and effects of inappropriate empirical antibiotic therapy for
bloodstream infections are unclear. We aimed to establish the population-level burden …

Importance Bloodstream infections (BSIs) are a major public health problem associated with
high morbidity. Little evidence exists regarding the epidemiology of BSIs and the use of …

Background Effective antimicrobial treatment is key for survival in bloodstream infection
(BSI), but the impact of timing of treatment remains unclear. Our aim was to assess the …

We investigated the impact of appropriate versus inappropriate initial antimicrobial therapy
on the clinical outcomes of patients with severe bacterial infections as part of a systematic …

Objectives: In line with the recent global action plan for antimicrobial resistance, this is the
first time such a comprehensive antimicrobial point prevalence survey has been undertaken …

Diagnosis of infectious diseases suffers from long turnaround times for gold standard culture-
based identification of bacterial pathogens, therefore impeding timely specific antimicrobial …

Introduction: In view of increasing concerns with antimicrobial resistance (AMR), the World
Health Organization (WHO) instituted a Global Action Plan (GAP) to address this. Area …

Background Antibiotics are extensively prescribed in intensive care units (ICUs), yet little is
known about how antibiotic-related decisions are made in this setting. We explored how …