Immune checkpoint blockade has revolutionized the field of oncology, inducing durable anti-
tumour immunity in solid tumours. In patients with advanced prostate cancer …

Steroid receptor coactivator 3 (SRC-3) is most strongly expressed in regulatory T cells
(Tregs) and B cells, suggesting that it plays an important role in the regulation of Treg …

Dysregulation of cholesterol is a common characteristic of human cancers including prostate
cancer. This study observed an aberrant accumulation of cholesteryl ester in metastatic …

Prostate cancer (PCa) is the major cause of cancer-related death in males; however,
effective treatments to prevent aggressive progression remain an unmet need. We have …

The gastrin-releasing peptide receptor (BB2r) is overexpressed in a variety of cancers
including prostate cancer. As a consequence, the development of BB2r-targeted …

Castration resistant-prostate cancer is largely impervious to feather hormonal therapy and
hence the outlook for patients is grim. Here we use an approach to attach the recently …

Skeletal metastasis is prevalent in many cancers, and has been the subject of intense
research, yielding innovative models to study the multiple stages of metastasis. It is now …

Previous study has suggested that the FABP5-PPARγ-signalling transduction pathway
gradually replaces the androgen receptor activated pathway in promoting malignant …

Wegener granulomatosis is a rare disease of unknown aetiology. In the majority of these
patients the kidney is involved in the disease process. We performed a case-control study to …

Increased cancer cell motility constitutes a root cause of end organ destruction and mortality,
but its complex regulation represents a barrier to precision targeting. We use the unique …