Several viruses infect the mammalian central nervous system (CNS), some with devastating
consequences, others resulting in chronic or persistent infections associated with little or no …

Frontotemporal lobar degeneration with tau (FTLD-tau) is a group of tauopathies that
underlie∼ 50% of FTLD cases. Identification of genetic risk variants related to …

Background The immune cell compartment of the mammalian brain changes dramatically
and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the …

The transcription factor Pax5 represses lineage-inappropriate genes and activates B cell-
specific genes in B lymphocytes. By identifying 110 Pax5-repressed genes, we now …

Immunotherapy using checkpoint-blocking antibodies against PD-1 has produced
impressive results in a wide range of cancers. However, the response remains …

The innate immune system is the first line of host defense against infection and involves
several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase …

The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …

The CC chemokine receptor type 5 (CCR5) is a key player in HIV infection due to its major
involvement in the infection process. Investigations into the role of the CCR5 coreceptor first …

The COVID-19 pandemic caused by the SARS-CoV-2 virus, overlaps with the ongoing
epidemics of cigarette smoking and electronic cigarette (e-cig) vaping. However, there is …

CCL3, a member of the CC-chemokine family, has been associated with macrophage
recruitment to heart tissue and parasite control in the acute infection of mouse with …