Strategies that generate tumor Ag-specific effector cells do not necessarily cure established
tumors. We hypothesized that the relative efficiency with which tumor-specific effector cells …

The addition of an appropriate adjuvant that activates the innate immunity is essential to
subsequent development of the adaptive immunity specific to the vaccine antigens. Thus …

Background: Granzymes are a subfamily of serine proteases involved in the pathogenesis of
many inflammatory disorders. In contrast with granzyme A and B, the role of granzyme K …

Mouse hepatitis virus strain JHM causes a chronic demyelinating disease in susceptible
strains of rodents. Demyelination does not develop in infected RAG1−/−(recombination …

Many neuroinflammatory diseases are characterized by massive immune cell infiltration into
the central nervous system. Identifying the underlying mechanisms could aid in the …

Neurotropic coronavirus-induced encephalitis was used to evaluate recruitment, functional
activation, and retention of peripheral bystander memory CD8+ T cells. Mice were first …

Rabies virus (RABV), the causative agent for rabies disease is still presenting a major public
health concern causing approximately 60,000 deaths annually. This neurotropic virus …

Introduction Coronaviruses are a large family of positive-stranded nonsegmented RNA
viruses with genomes of 26–32 kilobases in length. Human coronaviruses are commonly …

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental
contaminants, known to affect T lymphocytes. However, the molecular targets and pathways …

The role of CC chemokine receptor 1 (CCR1) in host defense and disease development was
determined in a model of viral-induced neurologic disease. Intracerebral (IC) infection of …