Bryostatin 1, a complex macrocyclic lactone, is the subject of multiple clinical trials for cancer
chemotherapy. Although bryostatin 1 biochemically functions like the classic mouse skin …

The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic
second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters, has …

Two approaches to the synthesis of compounds corresponding to the C17–C27 fragment of
the 20-deoxybryostatins are described. The first approach is based on the palladium (0) …

The first total synthesis of a derivative of a 20-deoxybryostatin, namely 7-des-O-pivaloyl-7-O-
benzylbryostatin 10 is described. Preliminary studies demonstrated that the modified Julia …

Important strides are being made in understanding the effects of structural features of
bryostatin 1, a candidate therapeutic agent for cancer and dementia, in conferring its …

Marine ecosystems show remarkable chemical, biological, and ecological diversities which
have inspired marine natural product chemists for many years to identify novel chemical …

The stereoselective synthesis of a carboxylic acid ester corresponding to the C1–C16
fragment of bryostatin, with 4-methoxybenzyl (PMB) protection for the 7-hydroxyl group, is …

Vinylic iodides were identified as useful intermediates for the synthesis of the C17-C27
fragment of the bryostatins with control of the geometry of the exocyclic …

Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety
were designed and synthesized. The derivatives with bulky substituents on the myo-inositol …

The modified Julia reaction and acyl carbanion chemistry, especially reactions of 2-lithiated
dithianes, have been investigated for the synthesis of intermediates that are the synthetic …