Heart failure is a clinical syndrome that is predominantly caused by cardiovascular disorders
such as coronary heart disease and hypertension. However, several classes of drugs may …

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Topical ophthalmic medications are widely prescribed by growing numbers of eye-care
professionals. Increasingly, these agents are being prescribed by optometrists and …

Since the late 1970s, topical β‐adrenergic blockers have been the drugs of choice in
treating ocular hypertension and associated glaucoma. The currently available drugs are …

Timolol maleate, a nonselective beta blocker, has been associated with adverse reactions
when administered topically or systemically. The current literature pertaining to timolol …

Since the introduction of ophthalmic timolol solution in 1978 there have been numerous
reports of systemic toxicity associated with its use. The majority of the systemic side effects …

OBJECTIVE: To review published clinical information on the systemic adverse effects of
ophthalmic β-blockers for the purpose of developing a pilot contraindication/warning system …

Glaucoma and ocular hypertension are highly prevalent conditions in individuals over the
age of 40 and are commonly seen together in patients with cardiovascular disease. Many of …

3. Discussion Ophthalmic timolol maleate is a nonselective topical beta-adrenergic receptor
blocking agent without significant sympathomimetic, direct myocardial depressant and …

Novel ketoxime analogues of known/3-blockers (propranolol, timolol, carteolol) were
synthesized and tested as potential site-specific chemical delivery systems. It was assumed …