Thiadiazole–A promising structure in design and development of anti-Alzheimer agents
M Hatami, Z Basri, BK Sakhvidi, M Mortazavi - International …, 2023 - Elsevier
The design and development of effective multitargeted agents in treating Alzheimer disease
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
Five-membered heterocyclic sulfonamides as carbonic anhydrase inhibitors
A Angeli, N Paoletti, CT Supuran - Molecules, 2023 - mdpi.com
The development of heterocyclic derivatives has progressed considerably over the past
decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field. In particular …
decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field. In particular …
[HTML][HTML] [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis …
MK Ghomi, M Noori, MN Montazer… - Scientific …, 2023 - ncbi.nlm.nih.gov
Regarding the important role of the urease enzyme as a virulence factor in urease-positive
microorganisms in this study, new series of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole …
microorganisms in this study, new series of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole …
The use of bis–thiadiazole and bis–oxadiazol derivatives as ionophores: a novel copper (II)–selective potentiometric electrodes
O Özbek, A Ölcenoglu - Microchemical Journal, 2023 - Elsevier
In this study, bis–thiadiazole and bis–oxadiazol derivative molecules were synthesized and
their ionophore properties were investigated. The synthesized bis–thiadiazole and bis …
their ionophore properties were investigated. The synthesized bis–thiadiazole and bis …
Novel oxadiazole-thiadiazole derivatives: synthesis, biological evaluation, and in silico studies
In the search for new anticancer agents, we synthesized a new series of thiazole derivatives
carried on thiadiazole-oxadiazole hybrid. Final compounds (5a–5i) were analyzed via 1H …
carried on thiadiazole-oxadiazole hybrid. Final compounds (5a–5i) were analyzed via 1H …
Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action
O Cil, MO Anderson, L de Souza Goncalves… - European journal of …, 2023 - Elsevier
The anion exchanger protein SLC26A3 (down-regulated in adenoma, DRA) is expressed in
the luminal membrane of intestinal epithelial cells in colon, where it facilitates the absorption …
the luminal membrane of intestinal epithelial cells in colon, where it facilitates the absorption …
Design, synthesis, in vitro acetylcholinesterase, butyrylcholinesterase activities, and in silico molecular docking study of oxindole-oxadiazole hybrid analogues
Alzheimer's disease is a neurological disorder characterized by cognitive dysfunction and
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …
deficits in activities of daily living. There is no drug available for Alzheimer's at the moment …
Dithiadiazole derivative 3-(4-nitrophenyl)-5-phenyl-3H-1, 2, 3, 4-dithiadiazole-2-oxide–Novel modulator of store-operated calcium entry
DA Grekhnev, IV Novikova, AV Krisanova… - Biochemical and …, 2022 - Elsevier
Pathological calcium homeostasis accompanies the development of a large number of
different diseases, therefore, the search for new modulators of calcium signaling remains …
different diseases, therefore, the search for new modulators of calcium signaling remains …
New N-(1,3,4-thiadiazole-2-yl)acetamide derivatives as human carbonic anhydrase I and II and acetylcholinesterase inhibitors
Various carbonic anhydrase (CA) enzyme isoforms are known today. In addition to the use
of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other …
of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other …
Emerging synthetic strategies and pharmacological insights of 1, 3, 4-thiadiazole derivatives: A comprehensive review
D Kumar, N Aggarwal, V Kumar, H Chopra… - Future Medicinal …, 2024 - Taylor & Francis
This review meticulously examines the synthesis techniques for 1, 3, 4-thiadiazole
derivatives, focusing on cyclization, condensation reactions and functional group …
derivatives, focusing on cyclization, condensation reactions and functional group …