Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western
countries and is characterized by the clonal expansion of mature CD5+ B cells. There have …

Somatic structural variants (SVs) are important drivers of cancer development and
progression. In a diagnostic set-up, especially for hematological malignancies, the …

Notch pathway signaling is implicated in several human cancers. Aberrant activation and
mutations of Notch signaling components are linked to tumor initiation, maintenance, and …

The final analysis of the open-label, multicenter phase 2 CLL2-GIVe trial shows response
and tolerability of the triple combination of obinutuzumab, ibrutinib, and venetoclax (GIVe …

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Despite its
indolent clinical course, therapy refractoriness and disease progression still represent an …

Richter transformation (RT) is the development of aggressive lymphoma–most frequently
diffuse large B-cell lymphoma (DLBCL) and rarely Hodgkin lymphoma (HL)–arising on the …

Simple Summary Chronic lymphocytic leukemia represents the most frequent leukemia in
adults and evolves from an indolent phase to an aggressive lymphoma in 5–10% of the …

The BCL6 corepressor (BCOR) is a transcription factor involved in the control of
embryogenesis, mesenchymal stem cells function, hematopoiesis, and lymphoid …

Background Acute leukemias represent deadly malignancies that require better treatment.
As a challenge, treatment is counteracted by a microenvironment protecting dormant …