[HTML][HTML] The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

A Shariati, M Arshadi, MA Khosrojerdi… - Frontiers in public …, 2022 - frontiersin.org
For around three decades, the fluoroquinolone (FQ) antibiotic ciprofloxacin has been used
to treat a range of diseases, including chronic otorrhea, endocarditis, lower respiratory tract …

[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

A microbe-derived efflux pump inhibitor of the resistance-nodulation-cell division protein restores antibiotic susceptibility in Escherichia coli and Pseudomonas …

R Tambat, N Mahey, N Chandal, DK Verma… - ACS Infectious …, 2022 - ACS Publications
The use of efflux pump inhibitors (EPIs) as potentiators along with the traditional antibiotics
assists in the warfare against antibiotic-resistant superbugs. Efflux pumps of the resistance …

[HTML][HTML] The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus

J Stephen, F Salam, M Lekshmi, SH Kumar, MF Varela - Antibiotics, 2023 - mdpi.com
The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public
health concern for centuries. Throughout its evolutionary course, S. aureus has developed …

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

G Kumar, AK Tudu - Bioorganic & Medicinal Chemistry, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is a pathogen responsible for various community and
hospital-acquired infections with life-threatening complications like bacteraemia …

Repurposing approved drugs as fluoroquinolone potentiators to overcome efflux pump resistance in Staphylococcus aureus

N Mahey, R Tambat, N Chandal, DK Verma… - Microbiology …, 2021 - Am Soc Microbiol
Staphylococcus aureus is a versatile human commensal bacteria and pathogen that causes
various community and hospital-acquired infections. The S. aureus efflux pump NorA which …

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

N Chandal, R Tambat, R Kalia, G Kumar… - Microbiology …, 2023 - Am Soc Microbiol
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to
fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also …

The cell–cell communication signal indole controls the physiology and interspecies communication of Acinetobacter baumannii

B Cui, X Chen, Q Guo, S Song, M Wang… - Microbiology …, 2022 - Am Soc Microbiol
Many bacteria utilize quorum sensing (QS) to control group behavior in a cell density-
dependent manner. Previous studies have demonstrated that Acinetobacter baumannii …

Antifungal azoles as tetracycline resistance modifiers in Staphylococcus aureus

N Mahey, R Tambat, DK Verma… - Applied and …, 2021 - Am Soc Microbiol
Staphylococcus aureus has developed resistance to antimicrobials since their first use. The
S. aureus major facilitator superfamily (MFS) efflux pump Tet (K) contributes to resistance to …

[HTML][HTML] Advances in the Discovery of Efflux Pump Inhibitors as Novel Potentiators to Control Antimicrobial-Resistant Pathogens

S Zhang, J Wang, J Ahn - Antibiotics, 2023 - mdpi.com
The excessive use of antibiotics has led to the emergence of multidrug-resistant (MDR)
pathogens in clinical settings and food-producing animals, posing significant challenges to …