Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Impaired neurovascular coupling in aging and Alzheimer's disease: contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

S Tarantini, CHT Tran, GR Gordon, Z Ungvari… - Experimental …, 2017 - Elsevier
The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

MRI of healthy brain aging: A review

ME MacDonald, GB Pike - NMR in Biomedicine, 2021 - Wiley Online Library
We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

Cerebral blood flow alterations in acute sport-related concussion

Y Wang, LD Nelson, AA LaRoche, AY Pfaller… - Journal of …, 2016 - liebertpub.com
Sport-related concussion (SRC) is a major health problem, affecting millions of athletes each
year. While the clinical effects of SRC (eg, symptoms and functional impairments) typically …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

Age‐related changes of normal cerebral and cardiac blood flow in children and adults aged 7 months to 61 years

C Wu, AR Honarmand, S Schnell, R Kuhn… - Journal of the …, 2016 - Am Heart Assoc
Background Cerebral and cardiac blood flow are important to the pathophysiology and
development of cerebro‐and cardiovascular diseases. The purpose of this study was to …

Multimodal biological brain age prediction using magnetic resonance imaging and angiography with the identification of predictive regions

P Mouches, M Wilms, D Rajashekar… - Human brain …, 2022 - Wiley Online Library
Biological brain age predicted using machine learning models based on high‐resolution
imaging data has been suggested as a potential biomarker for neurological and …

Variability of physiological brain perfusion in healthy subjects–A systematic review of modifiers. Considerations for multi-center ASL studies

P Clement, HJ Mutsaerts, L Václavů… - Journal of Cerebral …, 2018 - journals.sagepub.com
Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

Normative cerebral hemodynamics in middle-aged and older adults using 4D flow MRI: initial analysis of vascular aging

GS Roberts, A Peret, EM Jonaitis, RL Koscik… - Radiology, 2023 - pubs.rsna.org
Background Characterizing cerebrovascular hemodynamics in older adults is important for
identifying disease and understanding normal neurovascular aging. Four-dimensional (4D) …

Trends in prevalence of hypertension and hypertension phenotypes among Chinese children and adolescents over two decades (1991–2015)

X Ye, Q Yi, J Shao, Y Zhang, M Zha, Q Yang… - Frontiers in …, 2021 - frontiersin.org
Background: Hypertension is a leading cause of cardiovascular-related morbidity and
mortality. Elevated blood pressure (BP) in children is related to long-term adverse health …