Background: Brain insulin resistance is a well-recognized abnormality in Alzheimer's
disease (AD) and the likely mediator of impaired glucose utilization that emerges early and …

Neurodegenerative disorders are characterized by complex multifactorial pathogeneses,
thus posing a challenge for standard therapeutic approaches that tend to focus only on one …

We recently found that insoluble Aβ increases, but soluble Aβ decreases with age in normal
brains. We now report the changes in activities of β‐secretase (BACE‐1) and Aβ‐degrading …

Background: The interaction of aging-related, genetic, and environmental factors is thought
to contribute to the etiology of late-onset, sporadic Alzheimer's disease (AD). We previously …

Kynurenic acid (KYNA), one of the main product of the kynurenine pathway originating from
tryptophan, is considered to be neuroprotective. Dysregulation of KYNA activity is thought to …

Background: Pesticide residues have contaminated our environment and nutrition over the
last century. Although these compounds are present at very low concentrations, their long …

Alzheimer's disease (AD) is characterised by the aggregation and deposition of amyloid-β
(Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation and …

Background Alzheimer's disease (AD) and age-related macular degeneration (AMD) share
several pathological hallmarks including β-amyloid (Aβ) accumulation, oxidative stress, and …

Introduction• Targets and ongoing research‐NGF‐Neurotrophic function of NGF‐Levels of
NGF in AD‐Role of NGF in AD‐NGF as a therapeutic agent‐Development of NGF gene …

Epidemiological data associate hypertension with a predisposition to Alzheimer's disease
(AD), and a number of postmortem and in vivo studies also demonstrate that hypertension …