Although an association between diabetes mellitus (DM) and cognitive dysfunction has
been recognized for a century, it is often not considered as a complication of DM and …

Alzheimer's Diseases (AD) is characterized by the accumulation of amyloid deposits of Aβ
peptide in the brain. Besides genetic background, the presence of other diseases and an …

Accumulation of neurotoxic amyloid‐β peptide (Aβ) and alteration of metal homeostasis
(metallostasis) in the brain are two main factors that have been very often associated with …

The last decades have witnessed an explosion in studies of the role of amyloid-β (Aβ) in the
progress of the neurodegenerative disorder Alzheimer´ s disease (AD) and it is now widely …

There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its
accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes …

Alzheimer disease is one of the most challenging demons in our society due to its very high
prevalence and its clinical manifestations which cause deterioration of cognition …

Accumulating evidence indicates that over-stimulation of angiotensin-converting enzyme 1
(ACE1) activity is associated with β-amyloid (Aβ) and phosphorylated tau (p-tau)-induced …

Abstract Sacubitril/valsartan (Entresto™; LCZ696) is the first angiotensin receptor-neprilysin
inhibitor (ARNI) drug approved by the US and EU for heart failure (HF) and especially …

Fibrillar amyloid plaques are largely composed of amyloid‐beta (Aβ) peptides that are
metabolized into products, including Aβ1‐16, by proteases including matrix …

Diabetes mellitus (DM) is one of the major non-genetic risk factors for Alzheimer disease
(AD). However, the mechanism by which DM increases the risk of AD has not been …