Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of
several human diseases. NPCs provide access to the nucleus and regulate the transport of …

The nucleolus is a dynamic subnuclear structure with roles in ribosome subunit biogenesis,
mediation of cell-stress responses and regulation of cell growth. The proteome and structure …

The cell cycle-dependent nucleocytoplasmic transport of proteins is predominantly regulated
by CDK kinase activities; however, it is currently difficult to predict the proteins thus …

We present a thorough analysis of nuclear export signals and a prediction server, which we
have made publicly available. The machine learning prediction method is a significant …

The expansion of a polyglutamine tract in the ubiquitously expressed huntingtin protein
causes Huntington's disease (HD), a dominantly inherited neurodegenerative disease. We …

Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates the transcriptional response of
cells to oxidative stress and is translocated into the nucleus following, or concomitant with …

Protein export from the nucleus is often mediated by a Leucine-rich Nuclear Export Signal
(NES). NESbase is a database of experimentally validated Leucine-rich NESs curated from …

The adenovirus VA1 RNA (VA1), a 160-nucleotide (nt)-long RNA transcribed by RNA
polymerase III, is efficiently exported from the nucleus to the cytoplasm of infected cells …

Proteins bearing nuclear export signals (NESs) are translocated to the cytoplasm from the
nucleus mainly through the CRM1‐dependent pathway. However, the NES consensus …

Influenza is a global health concern, causing death, morbidity, and economic losses.
Chemotherapeutics that target influenza virus are available; however, rapid emergence of …