Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer …

Chronic obstructive pulmonary disease (COPD) is a frequent comorbid condition associated
with increased morbidity and mortality. Pneumonia is the most common infectious disease …

Background The current Global initiative for chronic Obstructive Lung Disease (GOLD)
treatment strategy recommends the use of one or more bronchodilators according to the …

Background Real-world prescription pathways leading to triple therapy (TT)(inhaled
corticosteroid [ICS] plus long-acting β2-agonist bronchodilator [LABA] plus long-acting …

Inhaled corticosteroids (ICSs) are a mainstay of COPD treatment for patients with a history of
exacerbations. Initial studies evaluating their use as monotherapy failed to show an effect on …

Identifying patients at risk of exacerbations and managing them appropriately to reduce this
risk represents an important clinical challenge. Numerous treatments have been assessed …

Objective Appropriate use of antibiotics in the management of hospitalised patients with
COPD exacerbations is defined within the GOLD strategy. This paper analyses the factors …

Objectives Protopathic bias is a systematic error which occurs when measured exposure
status may be affected by the latent onset of the target outcome. In this article, we aimed to …

Background Electronic medical records (EMRs) contain large amounts of rich clinical
information. Developing EMR-based case definitions, also known as EMR phenotyping, is …

Introduction: The frequent use of inhaled corticosteroids (ICSs), especially at higher doses,
has been accompanied by concern about both systemic and local side effects. Patients …