Immunosuppressant drugs (ISDs) are routinely used in clinical practice to maintain organ
transplant survival. However, these drugs are characterized by a restricted therapeutic …

Objective The study aimed to systematically evaluate the relationship between CYP3A5* 3
gene polymorphisms and the blood concentration and effectiveness of tacrolimus (TAC) in …

Tacrolimus, an immunosuppressant used in solid organ transplantation, has a narrow
therapeutic index and exhibits inter-individual pharmacokinetic variability. Achieving and …

Itraconazole is a triazole anti-infective drug that has been proven to prevent and treat a
variety of fungal and viral infections and has been considered to be a potential therapeutic …

Background: This study examines the impact of CYP3A4 and CYP 3A5 genotypes on
tacrolimus (Tac) pharmacokinetics in Romanian kidney transplanted patients. Methods: We …

Background/Aim: There exists considerably large interpatient variability in pharmacokinetic
exposure of high dose melphalan in multiple myeloma patients with hematopoietic stem-cell …

Abstract Background/Aim: There exists considerably large interpatient variability in
pharmacokinetic exposure of high dose melphalan in multiple myeloma patients with …

Background The main goal of immunosuppressive agents is to reach a balance of
preserving allograft function while minimizing adverse effects. The purpose of our research …

The unpredictable oral bioavailability of established drugs like tacrolimus and sulfasalazine
presents a significant clinical challenge. This variability can lead to either toxicity or …

Background Intravenous corticosteroid is the mainstay for managing acute severe ulcerative
colitis, but one-third of patients do not respond to intravenous corticosteroid. Tacrolimus, a …