Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets

S Nian, ACY Lo, Y Mi, K Ren, D Yang - Eye and Vision, 2021 - Springer
Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading
cause of visual loss in working-age individuals in many industrialized countries. It has been …

Retinal vascular endothelial cell dysfunction and neuroretinal degeneration in diabetic patients

M Mrugacz, A Bryl, K Zorena - Journal of clinical medicine, 2021 - mdpi.com
Diabetes mellitus (DM) has become a vital societal problem as epidemiological studies
demonstrate the increasing incidence of type 1 and type 2 diabetes. Lesions observed in the …

[PDF][PDF] Age-related macular degeneration (AMD): pathogenesis and therapy

JZ Nowak - Pharmacological reports, 2006 - Citeseer
Age-related macular degeneration (AMD) is a disease leading to severe visual loss and
legal blindness in the elderly population. Its pathogenesis, likely multifactorial, involving a …

Diabetic macular ischaemia-a new therapeutic target?

CMG Cheung, A Fawzi, KYC Teo, H Fukuyama… - Progress in Retinal and …, 2022 - Elsevier
Diabetic macular ischaemia (DMI) is traditionally defined and graded based on the
angiographic evidence of an enlarged and irregular foveal avascular zone. However, these …

Wnt Signaling in vascular eye diseases

Z Wang, CH Liu, S Huang, J Chen - Progress in retinal and eye research, 2019 - Elsevier
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

[HTML][HTML] The retinal pigmentation pathway in human albinism: Not so black and white

R Bakker, EL Wagstaff, CC Kruijt, E Emri… - Progress in retinal and …, 2022 - Elsevier
Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …

Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence

R Simo, C Hernandez - Progress in Retinal and eye Research, 2015 - Elsevier
Diabetic retinopathy remains as a leading cause of blindness in developed countries.
Current treatments target late stages of DR when vision has already been significantly …

The innate immune system in diabetic retinopathy

WW Pan, F Lin, PE Fort - Progress in retinal and eye research, 2021 - Elsevier
The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

Diabetic retinopathy–an underdiagnosed and undertreated inflammatory, neuro-vascular complication of diabetes

SH Sinclair, SS Schwartz - Frontiers in Endocrinology, 2019 - frontiersin.org
Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-
threatening condition, is one of the most common diabetes-specific complications. Diabetic …