Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

The human endothelin-1 (ET-1) gene under the control of its natural promoter was
transferred into the germline of mice. The transgene was expressed predominantly in the …

Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has
a wide range of roles both physiologically and pathologically. In recent years, there has …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

Endothelin A (ETA) receptor blockade has prevented vascular remodeling in aldosterone
and salt-induced hypertension. To evaluate effects of the ETA receptor antagonist, BMS …

In this review, we attempt to outline the age-dependent interactions of principal systems
controlling the structure and function of the cardiovascular system in immature rats …

Background In vitro studies on vascular smooth muscle cells suggest that endothelin has a
stimulating effect on cellular proliferation. This study was designed to determine the …