The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue
homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding …

The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Vascular
endothelial growth factor (VEGF) is an endothelial-specific growth factor that promotes …

Endothelial hyperpermeability is a significant problem in vascular inflammation associated
with trauma, ischaemia–reperfusion injury, sepsis, adult respiratory distress syndrome …

This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …

The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma
extravasation and vascular collapse accompanied by hemoconcentration and …

The clinical complications of atherosclerosis are caused by thrombus formation, which in
turn results from rupture of an unstable atherosclerotic plaque. The formation of …

Rationale: Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and
vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals …

Microvascular barrier dysfunction is implicated in the initiation and progression of
inflammation, posttraumatic complications, sepsis, ischaemia–reperfusion injury …