Introduction: Glucocorticoids represent the standard therapy for reducing inflammation and
immune activation in various diseases. However, as with any potent medication, they are not …

There is convincing evidence for the known and unambiguously accepted beneficial effects
of glucocorticoids at low dosages. However, the implementation of existing …

The purpose of this document, a result of the harmonisation and revision of Guidelines
published separately by the SIMFER, SIOMMMS/SIR, and SIOT associations, is to provide …

Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole
body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium …

Background Osteoblasts play important roles in the process of osteogenesis and prevention
of osteonecrosis. Dexamethasone (Dex), a type of glucocorticoids (GCs), induces apoptosis …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …

Long-term exposure to glucocorticoid (GC) contributes to the development of osteoporosis
(OP), which is correlated with the risk of fracture. Pathologically, GC-induced bone loss is …

Systemic glucocorticoids are an essential therapy for a range of conditions, but their multiple
side effects can produce significant morbidity for patients. The objective of this review is to …

Drug-induced osteoporosis is a significant health problem and many physicians are
unaware that many commonly prescribed medications contribute to significant bone loss …

Abstract Purpose of this Review The goal of the review is to provide an updated
understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment …