Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019

DJ Newman, GM Cragg - Journal of natural products, 2020 - ACS Publications
This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …

Antidiabetic phytochemicals from medicinal plants: prospective candidates for new drug discovery and development

S Alam, MMR Sarker, TN Sultana… - Frontiers in …, 2022 - frontiersin.org
Diabetes, a chronic physiological dysfunction affecting people of different age groups and
severely impairs the harmony of peoples' normal life worldwide. Despite the availability of …

[HTML][HTML] Pathways linking biodiversity to human health: A conceptual framework

MR Marselle, T Hartig, DTC Cox, S De Bell… - Environment …, 2021 - Elsevier
Biodiversity is a cornerstone of human health and well-being. However, while evidence of
the contributions of nature to human health is rapidly building, research into how biodiversity …

Coronavirus envelope protein: current knowledge

D Schoeman, BC Fielding - Virology journal, 2019 - Springer
Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

Plant based natural products as potential ecofriendly and safer biopesticides: A comprehensive overview of their advantages over conventional pesticides, limitations …

A Khursheed, MA Rather, V Jain, S Rasool, R Nazir… - Microbial …, 2022 - Elsevier
The commercially used synthetic pesticides have been proven to be toxic not only to
humans and other animals, but also to non-target plant, the surrounding organisms around …

Plant secondary metabolites produced in response to abiotic stresses has potential application in pharmaceutical product development

K Yeshi, D Crayn, E Ritmejerytė, P Wangchuk - Molecules, 2022 - mdpi.com
Plant secondary metabolites (PSMs) are vital for human health and constitute the skeletal
framework of many pharmaceutical drugs. Indeed, more than 25% of the existing drugs …

Techniques for extraction and isolation of natural products: A comprehensive review

QW Zhang, LG Lin, WC Ye - Chinese medicine, 2018 - Springer
Natural medicines were the only option for the prevention and treatment of human diseases
for thousands of years. Natural products are important sources for drug development. The …

Organic sonosensitizers for sonodynamic therapy: from small molecules and nanoparticles toward clinical development

D Li, Y Yang, D Li, J Pan, C Chu, G Liu - Small, 2021 - Wiley Online Library
Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low‐
intensity ultrasound and sonosensitizers. Versus photo‐mediated therapy, SDT has the …

Phenols in pharmaceuticals: analysis of a recurring motif

KA Scott, PB Cox, JT Njardarson - Journal of Medicinal Chemistry, 2022 - ACS Publications
Phenols and phenolic ethers are significant scaffolds recurring both in nature and among
approved small-molecule pharmaceuticals. This compendium presents the first …

Natural products for drug discovery in the 21st century: innovations for novel drug discovery

NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …