The confluence of big data and evolutionary genome mining for the discovery of natural products
This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …
genome mining tools has given rise to ever-growing genetic and chemical databases and …
Streptomyces cell-free systems for natural product discovery and engineering
Streptomyces bacteria are a major microbial source of natural products, which are encoded
within so-called biosynthetic gene clusters (BGCs). This highlight discusses the emergence …
within so-called biosynthetic gene clusters (BGCs). This highlight discusses the emergence …
Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster
Rare actinomycetes represent an underexploited source of new bioactive compounds. Here,
we report the use of a targeted metabologenomic approach to identify piperazyl compounds …
we report the use of a targeted metabologenomic approach to identify piperazyl compounds …
Comparative metabologenomics analysis of polar actinomycetes
Biosynthetic and chemical datasets are the two major pillars for microbial drug discovery in
the omics era. Despite the advancement of analysis tools and platforms for multi-strain …
the omics era. Despite the advancement of analysis tools and platforms for multi-strain …
Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes
Natural products possess significant therapeutic potential but remain underutilized despite
advances in genomics and bioinformatics. While there are approaches to activate and …
advances in genomics and bioinformatics. While there are approaches to activate and …
Myxadazoles, Myxobacterium‐Derived Isoxazole–Benzimidazole Hybrids with Cardiovascular Activities
Y Li, L Zhuo, X Li, Y Zhu, S Wu, T Shen… - Angewandte …, 2021 - Wiley Online Library
There is a continuous need for novel microbial natural products to fill the drying‐up drug
development pipeline. Herein, we report myxadazoles from Myxococcus sp. SDU36, a family …
development pipeline. Herein, we report myxadazoles from Myxococcus sp. SDU36, a family …
The design-build-test-learn cycle for metabolic engineering of streptomycetes
Streptomycetes are producers of a wide range of specialized metabolites of great medicinal
and industrial importance, such as antibiotics, antifungals, or pesticides. Having been the …
and industrial importance, such as antibiotics, antifungals, or pesticides. Having been the …
Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA
O Yushchuk, I Ostash, E Mösker, I Vlasiuk, M Deneka… - Scientific reports, 2021 - nature.com
Actinobacteria are among the most prolific sources of medically and agriculturally important
compounds, derived from their biosynthetic gene clusters (BGCs) for specialized …
compounds, derived from their biosynthetic gene clusters (BGCs) for specialized …
Constructing a myxobacterial natural product database to facilitate NMR-based metabolomics bioprospecting of myxobacteria
DG Wang, CY Wang, JQ Hu, JJ Wang, WC Liu… - Analytical …, 2023 - ACS Publications
Myxobacteria are fascinating prokaryotes featuring a potent capacity for producing a wealth
of bioactive molecules with intricate chemical topology as well as intriguing enzymology …
of bioactive molecules with intricate chemical topology as well as intriguing enzymology …
The virulome of Streptomyces scabiei in response to cello-oligosaccharide elicitors
B Deflandre, N Stulanovic, S Planckaert… - Microbial …, 2022 - microbiologyresearch.org
The development of spots or lesions symptomatic of common scab on root and tuber crops is
caused by few pathogenic Streptomyces with Streptomyces scabiei 87–22 as the model …
caused by few pathogenic Streptomyces with Streptomyces scabiei 87–22 as the model …