The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult
stem cell populations, which leads to hair greying in most humans and mice,. Current dogma …

Skin color, one of the most diverse human traits, is determined by the quantity, type, and
distribution of melanin. In this study, we leveraged the light-scattering properties of melanin …

Animals precisely control the morphology and assembly of guanine crystals to produce
diverse optical phenomena in coloration and vision. However, little is known about how …

Human skin and hair pigmentation play important roles in social behavior but also in
photoprotection from the harmful effects of ultraviolet light. The main pigments in mammalian …

Skin cutaneous melanoma (SKCM) is the deadliest form of skin cancer due to its high
heterogeneity that drives tumor aggressiveness. Melanoma plasticity consists of two distinct …

Albinism is a group of inherited disorders mainly affecting skin, hair and eyes. Here we
identify a de novo point mutation, p. R210C, in the TPCN2 gene which encodes Two Pore …

Epimedium brevicornum Maxim.(Epimedii Folium) is a traditional medicine widely utilized in
China for sexual dysfunction and osteoporosis treatment. Recently, studies have reported …

Hermansky–Pudlak syndrome (HPS) is characterized by defects of multiple tissue‐specific
lysosome‐related organelles (LROs), typically manifesting with oculocutaneous albinism or …