Targeting the RNA m6A modification for cancer immunotherapy

X Li, S Ma, Y Deng, P Yi, J Yu - Molecular cancer, 2022 - Springer
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

Emerging targeted therapies for HER2-positive breast cancer

MF Mercogliano, S Bruni, FL Mauro, R Schillaci - Cancers, 2023 - mdpi.com
Simple Summary HER2-positive breast cancer (BC), which accounts for~ 20% of BC, is one
of the more aggressive and has the worst overall survival rate among them. These patients …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Chimeric antigen receptor engineered natural killer cells for cancer therapy

Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

Prognostic biomarkers in uveal melanoma: The status quo, recent advances and future directions

NJ Lamas, A Martel, S Nahon-Estève, S Goffinet… - Cancers, 2021 - mdpi.com
Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Engineering induced pluripotent stem cells for cancer immunotherapy

Y Zhou, M Li, K Zhou, J Brown, T Tsao, X Cen… - Cancers, 2022 - mdpi.com
Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …

Innovative strategies to improve the clinical application of NK cell-based immunotherapy

M Tarannum, R Romee, RM Shapiro - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …

CAR-NK as a rapidly developed and efficient immunotherapeutic strategy against cancer

M Włodarczyk, B Pyrzynska - Cancers, 2022 - mdpi.com
Simple Summary New approaches in adoptive immunotherapy using chimeric antigen
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …

Generation and functional characterization of anti-CD19 chimeric antigen receptor-natural killer cells from human induced pluripotent stem cells

P Klaihmon, X Kang, S Issaragrisil… - International Journal of …, 2023 - mdpi.com
Natural killer (NK) cells are a part of innate immunity that can be activated rapidly in
response to malignant transformed cells without prior sensitization. Engineering NK cells to …