Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
Emerging targeted therapies for HER2-positive breast cancer
MF Mercogliano, S Bruni, FL Mauro, R Schillaci - Cancers, 2023 - mdpi.com
Simple Summary HER2-positive breast cancer (BC), which accounts for~ 20% of BC, is one
of the more aggressive and has the worst overall survival rate among them. These patients …
of the more aggressive and has the worst overall survival rate among them. These patients …
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …
Prognostic biomarkers in uveal melanoma: The status quo, recent advances and future directions
NJ Lamas, A Martel, S Nahon-Estève, S Goffinet… - Cancers, 2021 - mdpi.com
Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …
Engineering induced pluripotent stem cells for cancer immunotherapy
Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …
and differentiated into different types of immune cells, providing an unlimited resource for …
Innovative strategies to improve the clinical application of NK cell-based immunotherapy
Natural killer cells constitute a part of the innate immune system that mediates an effective
immune response towards virus-infected and malignant cells. In recent years, research has …
immune response towards virus-infected and malignant cells. In recent years, research has …
CAR-NK as a rapidly developed and efficient immunotherapeutic strategy against cancer
M Włodarczyk, B Pyrzynska - Cancers, 2022 - mdpi.com
Simple Summary New approaches in adoptive immunotherapy using chimeric antigen
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …
Generation and functional characterization of anti-CD19 chimeric antigen receptor-natural killer cells from human induced pluripotent stem cells
P Klaihmon, X Kang, S Issaragrisil… - International Journal of …, 2023 - mdpi.com
Natural killer (NK) cells are a part of innate immunity that can be activated rapidly in
response to malignant transformed cells without prior sensitization. Engineering NK cells to …
response to malignant transformed cells without prior sensitization. Engineering NK cells to …