Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

Ferroptosis is recently identified, an iron‐and reactive oxygen species‐(ROS‐) dependent
form of regulated cell death. This study was designed to determine the existence of …

Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

Skin, our first interface to the external environment, is subjected to oxidative stress caused
by a variety of factors such as solar ultraviolet, infrared and visible light, environmental …

Oxidative stress defines a condition in which the prooxidant–antioxidant balance in the cell
is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and …

Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and
signaling. Various oncogenic pathways such as proliferation and evading cell death …

Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …