Butyrate producers,“The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

V Singh, GD Lee, HW Son, H Koh, ES Kim… - Frontiers in …, 2023 - frontiersin.org
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological
importance than the other major SCFAs (acetate and propionate). Most butyrate producers …

The immunomodulatory functions of butyrate

MT Siddiqui, GAM Cresci - Journal of inflammation research, 2021 - Taylor & Francis
The gastrointestinal (GI) system contains many different types of immune cells, making it a
key immune organ system in the human body. In the last decade, our knowledge has …

Butyrate drives metabolic rewiring and epigenetic reprogramming in human colon cancer cells

L Wang, AAF Shannar, R Wu, P Chou… - Molecular nutrition & …, 2022 - Wiley Online Library
Scope Butyrate (B) is a short‐chain fatty acid produced by dietary fiber, known to inhibit
histone deacetylases (HDACs) and possess cancer‐preventive/anticancer effects. However …

Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines

R Hajjar, E Gonzalez, G Fragoso, M Oliero, AA Alaoui… - Gut, 2023 - gut.bmj.com
Objective Colorectal cancer (CRC) is the third most diagnosed cancer, and requires surgical
resection and reconnection, or anastomosis, of the remaining bowel to re-establish intestinal …

Organoid technologies for the study of intestinal microbiota–host interactions

V Bozzetti, S Senger - Trends in molecular medicine, 2022 - cell.com
Postbiotics have recently emerged as critical effectors of the activity of probiotics and,
because of their safety profile, they are considered potential therapeutics for the treatment of …

Biochemical and metabolical pathways associated with microbiota-derived butyrate in colorectal cancer and omega-3 fatty acids implications: A narrative review

AS Gheorghe, ȘM Negru, M Preda, RI Mihăilă… - Nutrients, 2022 - mdpi.com
Knowledge regarding the influence of the microbial community in cancer promotion or
protection has expanded even more through the study of bacterial metabolic products and …

Potential mechanisms of multimodal prehabilitation effects on surgical complications: a narrative review

D Sibley, M Chen, MA West, AG Matthew… - Applied Physiology …, 2023 - cdnsciencepub.com
Continuous advances in prehabilitation research over the past several decades have
clarified its role in improving preoperative risk factors, yet the evidence demonstrating …

Colorectal cancer: from risk factors to oncogenesis

VA Ionescu, G Gheorghe, N Bacalbasa, AL Chiotoroiu… - Medicina, 2023 - mdpi.com
Colorectal cancer is the second leading cause of cancer-related mortality worldwide.
Numerous pathophysiological mechanisms, such as abnormal cell proliferation, cell …

Gut-microbiota derived bioactive metabolites and their functions in host physiology

N Debnath, R Kumar, A Kumar, PK Mehta… - Biotechnology and …, 2021 - Taylor & Francis
Every individual harbours a complex, diverse and mutualistic microbial flora in their intestine
and over the time it became an integral part of the body, affecting a plethora of activities of …

[PDF][PDF] Microbiota-derived metabolites in colorectal cancer patients in preoperative period.

K Kaźmierczak-Siedlecka… - European Review for …, 2023 - ppm.gumed.edu.pl
OBJECTIVE: Short-chain fatty acids (SCFAs) are microbial derived metabolites, which have
multiple beneficial properties. The amount of SCFAs depends on several factors, such as …