In the early 1980's, the dispute on the existence of a multiplicity of receptors for
neurotransmitter was at its height. Several subtypes of serotonin (5-HT) receptors were …

DNA is the presumed target for a number of clinically useful anticancer drugs. In this review,
Laurence Hurley and Leslie Boyd discuss the appro~ ri~ terl~ ss of the term preceptor* for …

Purinergic modulation of mammalian tissue function was first demonstrated in 1929.
However, the lability of the purine and its ubiquitous distribution and function in mammalian …

Like many therapeutic substances derived from natural sources, the xanthine caffeine (1,
Fig. 1) has many thousands of years of documented human usage.'The compound has been …

Publisher Summary The promise of excitatory amino acids (EAAs) to afford new insights into
the structure and functioning of the central nervous system (CNS) and to provide new …

Publisher Summary This chapter describes long-lasting changes after perinatal exposure to
antidepressants. A great interest has arisen in the last fifteen years in the possible effects of …

Publisher Summary This chapter discusses the drugs that interact with central 5-HT
receptors. Serotonin may play a role in the etiology of depression, pain, various obsessive …

Radioligand binding studies have been instrumental in the discovery of 5-HT receptor
subtypes, but have clear limitations. By contrast, second messenger studies are elegant …

The endothelium-dependent acetylcholine, metacholine, carbachol, betanechol, and
furtretonium relaxation values have been measured in vitro for the rabbit aorta, in presence …

In an attempt to contain the chaos of receptor nomenclature, the supplement distributed with
this issue of TiPS catalogues cell surface receptors and their subtypes according to the most …