Major international practice guidelines recommend the use of a combination of 4 medication
classes in the treatment of patients with heart failure with reduced ejection fraction (HFrEF) …

Heart failure with reduced ejection fraction (HFrEF) is a clinical syndrome characterized by
volume overload, impaired exercise capacity, and recurrent hospital admissions. A major …

Aims Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations
govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy …

Abstract Background Neprilysin inhibitors (NEPi) are assisting the renin-angiotensin system
(RAS) inhibitors in halting diabetic cardiomyopathy (DCM). Away from conventional tactic, a …

The aims of the present study were to investigate the effects of angiotensin receptor
neprilysin inhibitors (ARNi) on the susceptibility of ventricular arrhythmias (VAs) in rats with …

BACKGROUND Duchenne muscular dystrophy (DMD), which is caused by a
mutation/deletion in the dystrophin gene on the X-chromosome, is the most common type of …

Pulmonary hypertension due to left heart disease (PH-LHD) represents approximately 65%–
80% of all patients with PH. The progression, prognosis, and mortality of individuals with left …

El tratamiento de los pacientes con insuficiencia cardiaca con fracción de eyección reducida
(IC-FEr) con una combinación de 4 clases de fármacos se recomienda en las principales …

Цель. Сравнение кардиопротективной эффективности валсартана/сакубитрила и
кандесартана у женщин с сердечной недостаточностью (СН) и исходно сниженной …

Chronic heart failure (CHF) is a serious public health problem in the world, which occurs
mostly in the elderly, with extremely high morbidity and mortality. The physiological changes …