Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …

Clinical and preclinical studies suggest that dysfunction of the glutamatergic system is
implicated in mood disorders such as major depressive disorder and bipolar depression. In …

Low doses of ketamine trigger rapid and lasting antidepressant effects after one injection in
treatment-resistant patients with major depressive disorder. Modulation of AMPA receptors …

The mechanism of action underlying ketamine's rapid antidepressant effects in patients with
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …

Concurrent with recent insights into the neuroprogressive nature of depression, ketamine
shows promise in interfering with several neuroprogressive factors, and has been suggested …

Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …

Converging clinical and preclinical evidence demonstrates that depressive phenotypes are
associated with synaptic dysfunction and dendritic simplification in cortico-limbic …

Background Lithium is the lightest metal and the only mood stabilizer that has been used for
over half a century for the treatment of bipolar disorder (BD). As a small ion, lithium is …

HMGB (high mobility group B) is one of the ubiquitous non-histone nuclear protein
superfamilies that make up the HMG (high mobility group) protein group. HMGB1 is involved …

Background Clinical studies have shown that the rapid antidepressant effect of the
glutamate N-methyl-D-aspartate receptor antagonist ketamine generally disappears within 1 …