The cornea is a tough transparent tissue admitting and focusing light in the eye. More than
90% of the cornea is stroma, a highly organized, transparent connective tissue maintained …

The corneal stroma comprises 90% of the corneal thickness and is critical for the cornea's
transparency and refractive function necessary for vision. When the corneal stroma is altered …

Corneal disease is considered as the second leading cause of vision loss and keratoplasty
is known as an effective treatment for it. However, the tissue engineered corneal substitutes …

Conventional allograft therapy for corneal scarring is widespread and successful, but donor
tissue is not universally available, and some grafts fail owing to rejection and complications …

Stem cell-based therapy has become an attractive and promising approach for the treatment
of severe injuries or thus-far incurable diseases. However, the use of stem cells is often …

Keratoconus is a disease characterized by progressive thinning, bulging, and distortion of
the cornea. Advanced cases usually present with loss of vision due to high irregular …

The corneal functions (transparency, refractivity and mechanical strength) deteriorate in
many corneal diseases but can be restored after corneal transplantation (penetrating and …

Collagen V is a regulatory fibril-forming collagen that forms heterotypic fibrils with collagen I.
Deletion of collagen V in the mouse is associated with a lack of fibril assembly in the …

The main treatment available for restoration of the corneal endothelium is keratoplasty. This
procedure is faced with several difficulties, including the shortage of donor tissue, post …

Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important
advantage of being easily obtained (in an autologous manner) from low invasive …