Molecular pathogenesis and mechanisms of thyroid cancer
M Xing - Nature Reviews Cancer, 2013 - nature.com
Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …
understanding its molecular pathogenesis in recent years, as best exemplified by the …
American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer …
DC Shonka Jr, A Ho, AV Chintakuntlawar… - Head & …, 2022 - Wiley Online Library
Background The development of systemic treatment options leveraging the molecular
landscape of advanced thyroid cancer is a burgeoning field. This is a multidisciplinary …
landscape of advanced thyroid cancer is a burgeoning field. This is a multidisciplinary …
Molecular genetics and diagnosis of thyroid cancer
YE Nikiforov, MN Nikiforova - Nature Reviews Endocrinology, 2011 - nature.com
Thyroid cancer is a common type of endocrine malignancy, and its incidence has been
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …
Comprehensive analysis of the transcriptional and mutational landscape of follicular and papillary thyroid cancers
Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable
by preoperative diagnosis due to their similar histological features. Here we report the first …
by preoperative diagnosis due to their similar histological features. Here we report the first …
Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA …
YE Nikiforov, NP Ohori, SP Hodak… - The Journal of …, 2011 - academic.oup.com
Context: Thyroid nodules are common in adults, but only a small fraction of them is
malignant. Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign …
malignant. Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign …
Novel targeted therapies and immunotherapy for advanced thyroid cancers
Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …
prognosis of this disease, 15–20% of differentiated thyroid cancer (DTC) cases and most …
Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer
MN Nikiforova, AI Wald, S Roy… - The Journal of …, 2013 - academic.oup.com
Objectives: Next-generation sequencing (NGS) allows for high-throughput sequencing
analysis of large regions of the human genome. We explored the use of targeted NGS for …
analysis of large regions of the human genome. We explored the use of targeted NGS for …
BRAF mutation in thyroid cancer
M Xing - Endocrine-related cancer, 2005 - erc.bioscientifica.com
Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon
which novel approaches to the management of thyroid cancer can be developed. A recent …
which novel approaches to the management of thyroid cancer can be developed. A recent …
BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications
M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …
received enthusiastic investigation, and significant progress has been made toward …
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
MN Nikiforova, ET Kimura, M Gandhi… - The Journal of …, 2003 - academic.oup.com
Activating point mutations of the BRAF gene have been recently reported in papillary thyroid
carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell …
carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell …