In recent years, significant progress has been achieved in genome editing applications
using new programmable DNA nucleases such as zinc finger nucleases (ZFNs) …

The chicken continues to hold its position as a leading model organism within many areas of
research, as well as being a major source of protein for human consumption. The First …

The rearing of farmed animals is a vital component of global food production systems, but its
impact on the environment, human health, animal welfare, and biodiversity is being …

In birds, males are the homogametic sex (ZZ) and females are the heterogametic sex (ZW).
Here, we investigate the role of chromosomal sex and germ cell competition on avian germ …

Over the last century, several reproductive biotechnologies beyond the artificial incubation of
eggs were developed to improve poultry breeding stocks and conserve their genetic …

In chickens, primordial germ cells (PGCs) are effective targets for advanced genome editing,
including gene knock-in. Although a long-term culture system has been established for …

The exuberant development of targeted genome editing has revolutionized research on the
chicken genome, generating chickens with beneficial parameters. The chicken model is a …

Many viral diseases affect the poultry industry worldwide and pose a devastating economic
impact in terms of morbidity and mortality. Generally, there is no treatment for these viral …

Primordial germ cells (PGCs), the precursors of sperm and oocytes, pass on the genetic
material to the next generation. The previously established culture system of chicken PGCs …

摘要家禽是重要的模式生物, 在农业和生物医学研究领域发挥重要作用. 近年来基因编辑工具
TALEN 和CRISPR/Cas9 在家禽转基因领域得以成功应用. 这些基因编辑技术可望用于提高 …