Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Importance Overt hyperthyroidism, defined assuppressed thyrotropin (previously thyroid-
stimulating hormone) and high concentration of triiodothyronine (T 3) and/or free thyroxine …

Background: Abnormal liver blood tests (LBTs) in hyperthyroid patients are not uncommonly
encountered. One major adverse event of antithyroid drug (ATD) therapy is drug-induced …

Prompt and stable control of hyperthyroidism is fundamental to avoid the detrimental effects
of thyroid hormone excess, and antithyroid drugs, mainly methimazole (MMI), represent the …

Background: Before the development of antithyroid drugs in the 1940s, treatment of Graves'
hyperthyroidism was primarily surgical. Surgical mortality was quite variable, but a …

Abstract Background The management of Graves' disease (GD) in the US is shifting towards
increased use of anti‐thyroid drugs (ATD). If patients fail to achieve remission after a …

Subclinical hyperthyroidism (SCH) is a laboratory diagnosis defined by a serum thyrotropin
(TSH) concentration below the reference range (< 0.4 mU/L in most assays), and a free …

Abstract Objective Treatment options for Graves' disease (GD) consist of antithyroid drugs
(ATD), radioactive iodine (RAI) and total thyroidectomy (TT). Guidelines recommend to …

Thionamide antithyroid drugs (ATD) are the treatment of choice for Graves' hyperthyroidism.
The major drawback of ATD treatment for 1–2 years is the relapse of hyperthyroidism in …

Graves' disease (GD) is an organ-specific autoimmune disease, but there are a few studies
that have evaluated how immunophenotypes are related to clinical symptoms and …