Clinical significance of tumor-infiltrating lymphocytes in breast cancer
SE Stanton, ML Disis - Journal for immunotherapy of cancer, 2016 - Springer
Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to
chemotherapy and improving clinical outcomes in all subtypes of breast cancer. Triple …
chemotherapy and improving clinical outcomes in all subtypes of breast cancer. Triple …
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
TR Simpson, SA Quezada, JP Allison - Current opinion in immunology, 2010 - Elsevier
Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is
upregulated on the surface of T cells following T cell activation and upon binding to its ligand …
upregulated on the surface of T cells following T cell activation and upon binding to its ligand …
Abundance of regulatory T cell (Treg) as a predictive biomarker for neoadjuvant chemotherapy in triple-negative breast cancer
Simple Summary Regulatory CD4+ T cell (Treg) is one of the suppressive immune cells, but
data on its clinical relevance in large human breast cancer cohort is limited. Abundance of …
data on its clinical relevance in large human breast cancer cohort is limited. Abundance of …
MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation
Background Allergic airway inflammation is triggered by allergen exposure through several
steps including release of IL-33, which promotes cytokine (IL-5, IL-13) production by type 2 …
steps including release of IL-33, which promotes cytokine (IL-5, IL-13) production by type 2 …
Integrated analysis of tertiary lymphoid structures in relation to tumor-infiltrating lymphocytes and patient survival in pancreatic ductal adenocarcinoma
T Tanaka, A Masuda, J Inoue, T Hamada… - Journal of …, 2023 - Springer
Background Tertiary lymphoid structure (TLS) reflects an intense immune response against
cancer, which correlates with favorable patient survival. However, the association of TLS …
cancer, which correlates with favorable patient survival. However, the association of TLS …
Regulatory T cells are associated with the tumor immune microenvironment and immunotherapy response in triple-negative breast cancer
P Huang, X Zhou, M Zheng, Y Yu, G Jin… - Frontiers in …, 2023 - frontiersin.org
Introduction Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer with a high risk of distant metastasis, an extremely poor prognosis, and a high risk of …
cancer with a high risk of distant metastasis, an extremely poor prognosis, and a high risk of …
ICOS mediates the generation and function of CD4+ CD25+ Foxp3+ regulatory T cells conveying respiratory tolerance
M Busse, M Krech, A Meyer-Bahlburg… - The Journal of …, 2012 - journals.aai.org
Costimulatory molecules like ICOS are crucial in mediating T cell differentiation and function
after allergen contact and thereby strongly affect the immunologic decision between …
after allergen contact and thereby strongly affect the immunologic decision between …
Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune …
X Zhang, R Ge, H Chen, M Ahiafor, B Liu… - Mediators of …, 2021 - Wiley Online Library
Follicular helper CD4+ T (TFH) cells are a specialized subset of effector T cells that play a
central role in orchestrating adaptive immunity. TFH cells mainly promote germinal center …
central role in orchestrating adaptive immunity. TFH cells mainly promote germinal center …
Predictive and prognostic role of peripheral blood T-cell subsets in triple-negative breast cancer
M Li, J Xu, C Jiang, J Zhang, T Sun - Frontiers in Oncology, 2022 - frontiersin.org
Background Triple-negative breast cancer (TNBC), as a highly aggressive and metastatic
tumor, can still not contain the medical needs. It has become an urgent problem to develop …
tumor, can still not contain the medical needs. It has become an urgent problem to develop …
CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulation
S Liu, Z Tao, J Lou, R Li, X Fu, J Xu, T Wang… - Journal of Translational …, 2023 - Springer
Background Tregs are key drivers of immunosuppression in solid tumors. As an important
chemokine receptor on Tregs, the regulatory effect of CCR8 on tumor immunity has received …
chemokine receptor on Tregs, the regulatory effect of CCR8 on tumor immunity has received …