Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Central obesity, measured by the waist circumference (WC) or waist-to-hip ratio, has been
linked with metabolic dysfunction and structural abnormalities in the brain, two risk factors for …

Background: Recent studies point to the adipose tissue as a highly active endocrine organ
secreting a range of hormones. Leptin, ghrelin, adiponectin, and resistin are considered to …

Objective To evaluate any association between obesity in middle age, measured by body
mass index and skinfold thickness, and risk of dementia later in life. Design Analysis of …

Background: Numerous reports show that a centralized distribution of adiposity is a more
dangerous risk factor for cardiovascular disease and diabetes than total body obesity. No …

Objective: To assess whether body mass index (BMI) is associated with cognitive function
and cognitive decline in healthy men and women. Methods: In this prospective cohort study …

A growing body of epidemiological evidence suggested that metabolic syndrome (MetS) and
Mets components (impaired glucose tolerance, abdominal or central obesity, hypertension …

The increasing ageing of our societies is accompanied by a pandemic of obesity and related
cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is …

Objective Midlife obesity has been associated with an increased risk of dementia. The
underlying mechanisms are poorly understood. Our aim was to examine the cross‐sectional …

If the new environment and modern lifestyle cause obesity in individuals with thrifty genes by
increasing energy intake, it is important to know by what mechanisms hyperphagia occurs …