Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Endocrine mechanisms have been largely associated with metabolic control and tissue
cross talk in mammals. Classically, myokines comprise a class of signaling proteins …

The gut microbiota has the capacity to affect host appetite via intestinal satiety pathways, as
well as complex feeding behaviors. In this Review, we highlight recent evidence that the gut …

Precise neural regulation is required for maintenance of energy homeostasis. Essential to
this are the hypothalamic and brainstem nuclei which are located adjacent and supra …

Oxytocin is a peptide‐hormone extensively studied for its multifaceted biological functions
and has recently gained attention for its role in eating behavior, through its action as an …

In experimental models, hypothalamic dysfunction is a key component of the
pathophysiology of diet-induced obesity. Early after the introduction of a high-fat diet …

Objective Free fatty acid receptor-1 (FFAR1) is a medium-and long-chain fatty acid sensing
G protein-coupled receptor that is highly expressed in the hypothalamus. Here, we …

Abstract In April 2023, the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), in partnership with the National Institute of Child Health and Human Development …

Hypothalamic inflammation and metabolic changes resulting from the consumption of high-
fat diets have been linked to low grade inflammation and obesity. Inflammation impairs the …

It is well established in mammals that the gastrointestinal tract (GIT) senses the luminal
presence of nutrients and responds to such information by releasing signaling molecules …