Significance: Chronic diabetic wounds on the lower extremities (diabetic foot ulcers, DFU)
are one of the most prevalent and life-threatening complications of diabetes, responsible for …

Thrombin is the product of the hemostatic response essential to the conversion of fibrinogen
to fibrin. In addition, it is also responsible for the aggregation of blood platelets in the …

Chronic wounds represent a significant medical burden. Such wounds fail to normally
progress through the stages of healing, often complicated by a proinflammatory milieu …

Diabetic foot ulcers (DFU) are common, difficult-to-treat, and prone to complications. A
prospective, controlled study was conducted to: 1) examine the clinical efficacy of a …

Elderly diabetic patients are particularly burdened by foot disease. The main causes for foot
disease are peripheral neuropathy, foot deformities and peripheral arterial disease (PAD) …

Aims/hypothesis Foot ulcers in people with diabetes are a common and serious global
health issue. Dressings form a key part of ulcer treatment. Existing systematic reviews are …

When treating diabetic foot ulcers it is important to be aware of the natural history of the
diabetic foot, which can be divided into five stages: stage 1, a normal foot; stage 2, a high …

Management of foot ulcer in individuals with diabetes remains a major therapeutic challenge
throughout the world. We performed a critical review of evidence of present and new …

Objective: We recently showed the superiority of a matrix metalloproteinase (MMP)
modulating dressing (foam impregnated with NOSF, nano-oligosaccharide factor) compared …

Background It is estimated that up to 1% of people in high‐income countries suffer from a leg
ulcer at some time in their life. The majority of leg ulcers are associated with circulation …