Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of
30,000 patients a year worldwide. The median reported survival time since onset ranges …

Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is
predicted to increase across the globe by~ 70% in the following decades. Understanding the …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Abstract Phosphorylated TDP-43 (pTDP-43) aggregates in the cytoplasm of motor neurons
and neuroglia in the brain are one of the pathological hallmarks of amyotrophic lateral …

Increasing evidence gives support for the idea that extra-neuronal factors may affect brain
physiology and its predisposition to neurodegenerative diseases. Epidemiological and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition where motor neurons
(MNs) degenerate. Most of the ALS cases are sporadic (sALS), whereas 10% are …

Superoxide dismutase (SOD) is a common antioxidant enzyme found majorly in living cells.
The main physiological role of SOD is detoxification and maintain the redox balance, acts as …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive degeneration of motor neurons, leading to muscle atrophy, paralysis and …

The concept, definition, and diagnosis of amyotrophic lateral sclerosis (ALS) currently
present some problems. This article systematically reviews the literature on the history …