[HTML][HTML] Evaluation of the association of chronic inflammation and cancer: Insights and implications

M Nigam, AP Mishra, VK Deb, DB Dimri, V Tiwari… - Biomedicine & …, 2023 - Elsevier
Among the most extensively researched processes in the development and treatment of
cancer is inflammatory condition. Although acute inflammation is essential for the wound …

[HTML][HTML] Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents

S Hashem, TA Ali, S Akhtar, S Nisar, G Sageena… - Biomedicine & …, 2022 - Elsevier
Cancer is one of the leading causes of death and significantly burdens the healthcare
system. Due to its prevalence, there is undoubtedly an unmet need to discover novel …

Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases:“reverse pharmacology” and “bedside to bench” approach

BB Aggarwal, S Prasad, S Reuter… - Current drug …, 2011 - ingentaconnect.com
Inflammation, although first characterized by Cornelius Celsus, a physician in first Century
Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a …

The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology

T Shen, GH Li, XN Wang, HX Lou - Journal of ethnopharmacology, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The resinous exudates of the Commiphora
species, known as 'myrrh', are used in traditional Chinese medicine for the treatment of …

Googling the Guggul (Commiphora and Boswellia) for prevention of chronic diseases

AB Kunnumakkara, K Banik, D Bordoloi… - Frontiers in …, 2018 - frontiersin.org
Extensive research during last 2 decades has revealed that most drugs discovered today,
although costs billions of dollars for discovery, and yet they are highly ineffective in their …

The multifaceted roles of STAT3 signaling in the progression of prostate cancer

JL Bishop, D Thaper, A Zoubeidi - Cancers, 2014 - mdpi.com
The signal transducer and activator of transcription (STAT) 3 governs essential functions of
epithelial and hematopoietic cells that are often dysregulated in cancer. While the role for …

The guggul for chronic diseases: ancient medicine, modern targets

S Shishodia, KB Harikumar, S Dass… - Anticancer …, 2008 - ar.iiarjournals.org
Identification of active principles and their molecular targets from traditional medicine is an
enormous opportunity for modern drug development. Gum resin from Commiphora wightii …

Plant sterol guggulsterone inhibits nuclear factor-κB signaling in intestinal epithelial cells by blocking IκB kinase and ameliorates acute murine colitis

JH Cheon, JS Kim, JM Kim, N Kim… - Inflammatory bowel …, 2006 - academic.oup.com
Abstract Background/Aims The plant sterol guggulsterone has been shown to have anti-
inflammatory properties. It remains unknown, however, whether guggulsterone is effective …

Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt …

S Shishodia, G Sethi, KS Ahn, BB Aggarwal - Biochemical pharmacology, 2007 - Elsevier
Guggulsterone is a plant polyphenol traditionally used to treat obesity, diabetes,
hyperlipidemia, atherosclerosis, and osteoarthritis, possibly through an anti-inflammatory …

Mechanisms of action of novel agents for prostate cancer chemoprevention

RP Singh, R Agarwal - Endocrine-related cancer, 2006 - erc.bioscientifica.com
Despite advances in the understanding of prostate cancer (PCa) growth and development, it
is still the leading incidence of cases and the second leading cause of mortality due to …