Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy
BH Xu, J Sheng, YK You, XR Huang, RCW Ma… - Metabolism, 2020 - Elsevier
Background Transforming growth factor (TGF)-β/Smad3 signaling is highly activated in
kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of …
kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of …
Endothelin-targeted new treatments for proteinuric and inflammatory glomerular diseases: focus on the added value to anti-renin-angiotensin system inhibition
A Benigni, S Buelli, DE Kohan - Pediatric Nephrology, 2021 - Springer
Chronic kidney disease (CKD) is the main cause of end-stage renal disease worldwide
arising as a frequent complication of diabetes, obesity, and hypertension. Current …
arising as a frequent complication of diabetes, obesity, and hypertension. Current …
Promising therapeutic mechanism for Chinese herbal medicine in ameliorating renal fibrosis in diabetic nephropathy
S Wang, S Qin, B Cai, J Zhan, Q Chen - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic nephropathy (DN) is one of the most serious chronic microvascular abnormalities of
diabetes mellitus and the major cause of uremia. Accumulating evidence has confirmed that …
diabetes mellitus and the major cause of uremia. Accumulating evidence has confirmed that …
Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy
K Shahzad, F Bock, MM Al-Dabet, I Gadi, S Nazir… - Scientific reports, 2016 - nature.com
While a plethora of studies support a therapeutic benefit of Nrf2 activation and ROS
inhibition in diabetic nephropathy (dNP), the Nrf2 activator bardoxolone failed in clinical …
inhibition in diabetic nephropathy (dNP), the Nrf2 activator bardoxolone failed in clinical …
Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice
JN Hong, WW Li, LL Wang, H Guo, Y Jiang, YJ Gao… - Chinese medicine, 2017 - Springer
Background Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia
humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena …
humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena …
The association of angiogenic factors and chronic kidney disease
CE Anderson, LL Hamm, G Batuman, DR Kumbala… - BMC nephrology, 2018 - Springer
Background There are limited data on the associations of circulating angiogenic factors with
chronic kidney disease (CKD). We investigate the associations of circulating vascular …
chronic kidney disease (CKD). We investigate the associations of circulating vascular …
Early and late scanning electron microscopy findings in diabetic kidney disease
S Conti, N Perico, R Novelli, C Carrara, A Benigni… - Scientific Reports, 2018 - nature.com
Diabetic nephropathy (DN), the single strongest predictor of mortality in patients with type 2
diabetes, is characterized by initial glomerular hyperfiltration with subsequent progressive …
diabetes, is characterized by initial glomerular hyperfiltration with subsequent progressive …
The Alcohol Extract of Coreopsis tinctoria Nutt Ameliorates Diabetes and Diabetic Nephropathy in db/db Mice through miR‐192/miR‐200b and PTEN/AKT and ZEB2 …
S Yu, H Zhao, W Yang, R Amat, J Peng… - BioMed research …, 2019 - Wiley Online Library
The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt
(AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 …
(AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 …
Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism
S Song, M Dang, M Kumar - Inflammopharmacology, 2019 - Springer
P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be
activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol …
activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol …
Beneficial effect on podocyte number in experimental diabetic nephropathy resulting from combined atrasentan and RAAS inhibition therapy
KL Hudkins, TA Wietecha, F Steegh… - American Journal of …, 2020 - journals.physiology.org
Podocyte loss and proteinuria are both key features of human diabetic nephropathy (DN).
The leptin-deficient BTBR mouse strain with the ob/ob mutation develops progressive weight …
The leptin-deficient BTBR mouse strain with the ob/ob mutation develops progressive weight …