[HTML][HTML] A review of the pathology and treatment of TBI and PTSD

M Monsour, D Ebedes, CV Borlongan - Experimental neurology, 2022 - Elsevier
This literature review focuses on the underlying pathophysiology of TBI and PTSD
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …

[HTML][HTML] Multipotent mesenchymal stem cell-based therapies for spinal cord injury: current progress and future prospects

CW Zeng - Biology, 2023 - mdpi.com
Simple Summary Mesenchymal stem cells (MSCs) are a promising option for developing
new treatments for spinal cord injury (SCI). They can help repair damaged tissue, making …

[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction

M Kodali, LN Madhu, RL Reger, B Milutinovic… - Brain, behavior, and …, 2023 - Elsevier
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …

Mesenchymal stem cell therapy: a potential treatment targeting pathological manifestations of traumatic brain injury

K Zhang, Y Jiang, B Wang, T Li… - … Medicine and Cellular …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) makes up a large proportion of acute brain injuries and is a
major cause of disability globally. Its complicated etiology and pathogenesis mainly include …

[HTML][HTML] Bone marrow stromal cells-derived exosomes reduce neurological damage in traumatic brain injury through the miR-124-3p/p38 MAPK/GLT-1 axis

Z Zhuang, M Liu, Z Dai, J Luo, B Zhang, H Yu… - Experimental …, 2023 - Elsevier
Background Mounting evidence indicates that stem cell-derived exosomal miRNAs have
therapeutic effects on traumatic brain injury (TBI). This research is focused on exploring the …

Mesenchymal stem cells (MSCs) and MSC‐derived exosomes in animal models of central nervous system diseases: targeting the NLRP3 inflammasome

S Nazari, SM Pourmand, E Motevaseli… - IUBMB …, 2023 - Wiley Online Library
Abstract The NLRP3 (NOD‐, LRR‐, and pyrin domain‐containing protein 3) inflammasome
is a multimeric protein complex that is engaged in the innate immune system and plays a …

[HTML][HTML] Human retinal secretome: A cross-link between mesenchymal and retinal cells

L Donato, C Scimone, S Alibrandi… - World Journal of Stem …, 2023 - ncbi.nlm.nih.gov
In recent years, mesenchymal stem cells (MSC) have been considered the most effective
source for regenerative medicine, especially due to released soluble paracrine bioactive …

[HTML][HTML] Boosting neurogenesis in the adult hippocampus using antidepressants and mesenchymal stem cells

M Kot, PK Neglur, A Pietraszewska, L Buzanska - Cells, 2022 - mdpi.com
The hippocampus is one of the few privileged regions (neural stem cell niche) of the brain,
where neural stem cells differentiate into new neurons throughout adulthood. However …

[HTML][HTML] Stem cell therapy for sequestration of traumatic brain injury-induced inflammation

MC Borlongan, S Rosi - International journal of molecular sciences, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of long-term neurological
disabilities in the world. TBI is a signature disease for soldiers and veterans, but also affects …

[HTML][HTML] Guideline of clinical neurorestorative treatment for brain trauma (2022 China version)

X Yang, L Chen, J Pu, Y Li, J Cai, L Chen… - Journal of …, 2022 - Elsevier
Brain trauma or traumatic brain injury (TBI) is one of the leading causes of death and
disability worldwide. Along with the conventional therapeutic strategies, neurorestorative …