Targeting DNA repair pathways for cancer treatment: what's new?
Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …
growing body of evidence indicates that tumors accumulate progressively more mutations in …
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents-A recent update
PG Jain, BD Patel - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Poly (ADP-ribose) Polymerase1 (PARP1) is a member of 17 membered PARP
family having diversified biological functions such as synthetic lethality, DNA repair …
family having diversified biological functions such as synthetic lethality, DNA repair …
The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1−/− murine model of ovarian cancer
J Huang, L Wang, Z Cong, Z Amoozgar, E Kiner… - Biochemical and …, 2015 - Elsevier
Familial breast and ovarian cancer are often caused by inherited mutations of BRCA1. While
current prognoses for such patients are rather poor, inhibition of poly-ADP ribose …
current prognoses for such patients are rather poor, inhibition of poly-ADP ribose …
[HTML][HTML] Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer
F Rojo, J Garcia-Parra, S Zazo, I Tusquets… - Annals of oncology, 2012 - Elsevier
Background Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly promising novel target in
breast cancer. However, the expression of PARP-1 protein in breast cancer and its …
breast cancer. However, the expression of PARP-1 protein in breast cancer and its …
[图书][B] DNA damage, DNA repair and cancer
C Bernstein, AR Prasad, V Nfonsam, H Bernstein - 2013 - books.google.com
DNA damage appears to be a fundamental problem for life. In this chapter we review evi‐-
dence indicating that DNA damages are a major primary cause of cancer. DNA damages …
dence indicating that DNA damages are a major primary cause of cancer. DNA damages …
[HTML][HTML] PET imaging of PARP expression using 68Ga-labelled inhibitors
X Wang, W Liu, K Li, K Chen, S He, J Zhang… - European Journal of …, 2023 - Springer
Purpose Imaging the PARP expression using 18F probes has been approved in clinical
trials. Nevertheless, hepatobiliary clearance of both 18F probes hindered their application in …
trials. Nevertheless, hepatobiliary clearance of both 18F probes hindered their application in …
[HTML][HTML] Autophagy and genomic integrity
DNA lesions, constantly produced by endogenous and exogenous sources, activate the
DNA damage response (DDR), which involves detection, signaling and repair of the …
DNA damage response (DDR), which involves detection, signaling and repair of the …
Metformin is synthetically lethal with glucose withdrawal in cancer cells
JA Menendez, C Oliveras-Ferraros, S Cufí… - Cell cycle, 2012 - Taylor & Francis
Glucose deprivation is a distinctive feature of the tumor microecosystem caused by the
imbalance between poor supply and an extraordinarily high consumption rate. The …
imbalance between poor supply and an extraordinarily high consumption rate. The …
[HTML][HTML] p53 regulates a non-apoptotic death induced by ROS
J Montero, C Dutta, D Van Bodegom… - Cell Death & …, 2013 - nature.com
DNA damage induced by reactive oxygen species and several chemotherapeutic agents
promotes both p53 and poly (ADP-ribose) polymerase (PARP) activation. p53 activation is …
promotes both p53 and poly (ADP-ribose) polymerase (PARP) activation. p53 activation is …
Mechanisms of doxorubicin-mediated reproductive toxicity–a review
The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …
including reproductive toxicity in both genders. The current review has complied the …