Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …

Aquaporins (AQPs) are ubiquitous membrane proteins whose identification, pioneered by
Peter Agre's team in the early nineties, provided a molecular basis for transmembrane water …

Water homeostasis in the brain is of central physiologic and clinical importance. Neuronal
activity and ion water homeostasis are inextricably coupled. For example, the clearance of …

As nanometer-scale portals in biological membranes, protein ionic channels act as
gatekeepers, controlling the traffic of ions and macromolecules into and out of cells …

Pilewski, Joseph M., and Raymond A. Frizzell. Role of CFTR in Airway Disease. Physiol.
Rev. 79, Suppl.: S215–S255, 1999.—Cystic fibrosis (CF) is caused by mutations in the gene …

Background information. MIPs (major intrinsic proteins) form channels across biological
membranes that control recruitment of water and small solutes such as glycerol and urea in …