HE4 as a Biomarker for Endometrial Cancer

R Behrouzi, CE Barr, EJ Crosbie - Cancers, 2021 - mdpi.com
Simple Summary There are currently no blood biomarkers approved for routine clinical use
in endometrial cancer. Serum human epididymis protein 4 (HE4) is significantly higher in …

Urinary biomarkers and their potential for the non-invasive detection of endometrial cancer

K Njoku, D Chiasserini, ER Jones, CE Barr… - Frontiers in …, 2020 - frontiersin.org
Endometrial cancer is the most common malignancy of the female genital tract and its
incidence is rising in parallel with the mounting prevalence of obesity. Early diagnosis has …

Upgrading Treatment and Molecular Diagnosis in Endometrial Cancer—Driving New Tools for Endometrial Preservation?

M Dellino, M Cerbone, AS Laganà, A Vitagliano… - International Journal of …, 2023 - mdpi.com
One emerging problem for onco-gynecologists is the incidence of premenopausal patients
under 40 years of age diagnosed with stage I Endometrial Cancer (EC) who want to …

Proteomic biomarkers for the detection of endometrial cancer

K Njoku, D Chiasserini, AD Whetton, EJ Crosbie - Cancers, 2019 - mdpi.com
Endometrial cancer is the leading gynaecological malignancy in the western world and its
incidence is rising in tandem with the global epidemic of obesity. Early diagnosis is key to …

[HTML][HTML] The emerging role of HE4 in the evaluation of advanced epithelial ovarian and endometrial carcinomas

AR Simmons, K Baggerly, RC Bast Jr - Oncology (Williston Park …, 2013 - ncbi.nlm.nih.gov
Abstract HE4 (human epididymis protein 4) is overexpressed in both ovarian and
endometrial cancers. Levels of the shed HE4 protein are elevated in sera from ovarian and …

HE4 tissue expression and serum HE4 levels in healthy individuals and patients with benign or malignant tumors: a systematic review

NS Karlsen, MA Karlsen, CK Høgdall… - … , Biomarkers & Prevention, 2014 - AACR
Abstract Human epididymis protein 4 (HE4) has received major attention as a potential
tumor marker in epithelial ovarian cancer; however, evidence of significant overexpression …

Ovarian cancer recurrence and early detection: may HE4 play a key role in this open challenge? A systematic review of literature

S Capriglione, D Luvero, F Plotti, C Terranova… - Medical Oncology, 2017 - Springer
Despite the improvement in overall survival for ovarian cancer (OC) patients, a fraction of
patients with advanced-stage disease fails to respond to primary therapy and relapses in …

HE 4 and CA 125 levels in the preoperative assessment of endometrial cancer patients: a prospective multicenter study (ENDOMET)

SL Antonsen, E Høgdall, IJ Christensen… - Acta obstetricia et …, 2013 - Wiley Online Library
Objective To evaluate whether human epididymis protein 4 (HE 4) and CA 125 correlate
with known high‐risk prognostic factors for endometrial cancer. Design Prospective …

Discovery of biomarkers for endometrial cancer: current status and prospects

TL Rižner - Expert review of molecular diagnostics, 2016 - Taylor & Francis
Introduction: Endometrial cancer is the most frequent gynecological malignancy in the
developed world. Currently, endometrial histology is the gold standard for diagnosis, as …

Can the preoperative HE4 level predict optimal cytoreduction in patients with advanced ovarian carcinoma?

R Angioli, F Plotti, S Capriglione, A Aloisi… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: Optimal surgical outcome has been proved to be one of the most powerful
survival determinants in the management of ovarian cancer patients. Actually, for ovarian …