Development of micro RNA therapeutics is coming of age

E Van Rooij, S Kauppinen - EMBO molecular medicine, 2014 - embopress.org
Micro RNA s (mi RNA s) play key regulatory roles in diverse biological processes and are
frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of …

Inhibition of microRNA function by antimiR oligonucleotides

J Stenvang, A Petri, M Lindow, S Obad, S Kauppinen - Silence, 2012 - Springer
MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression in many developmental and cellular processes. Moreover, there is now ample …

Silencing of microRNA families by seed-targeting tiny LNAs

S Obad, CO dos Santos, A Petri, M Heidenblad… - Nature …, 2011 - nature.com
The challenge of understanding the widespread biological roles of animal microRNAs
(miRNAs) has prompted the development of genetic and functional genomics technologies …

MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2

J Hou, P Wang, L Lin, X Liu, F Ma, H An… - The journal of …, 2009 - journals.aai.org
Upon recognition of viral components by pattern recognition receptors, including TLRs and
retinoic acid-inducible gene I (RIG-I)-like helicases, cells are activated to produce type I IFN …

DIANA-microT 2023: including predicted targets of virally encoded miRNAs

S Tastsoglou, A Alexiou, D Karagkouni… - Nucleic acids …, 2023 - academic.oup.com
DIANA-microT-CDS is a state-of-the-art miRNA target prediction algorithm catering the
scientific community since 2009. It is one of the first algorithms to predict miRNA binding …

Discovering the first microRNA-targeted drug

M Lindow, S Kauppinen - 2012 - rupress.org
MicroRNAs (miRNAs) are important post-transcriptional regulators of nearly every biological
process in the cell and play key roles in the pathogenesis of human disease. As a result …

MicroRNA involvement in signaling pathways during viral infection

MG Barbu, CE Condrat, DC Thompson… - Frontiers in cell and …, 2020 - frontiersin.org
The study of miRNAs started in 1993, when Lee et al. observed their involvement in the
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …

Reactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus: an update

KK Aneja, Y Yuan - Frontiers in microbiology, 2017 - frontiersin.org
The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases,
latent and lytic. The virus establishes latency as a strategy for avoiding host immune …

[HTML][HTML] Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells

D Nachmani, N Stern-Ginossar, R Sarid… - Cell host & …, 2009 - cell.com
Herpesviruses are known for their persistent lifelong latent infection, which is made possible
by their vast repertoire of immune-evasion strategies. We have previously shown that a …

An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

EYW Choy, KL Siu, KH Kok, RWM Lung… - The Journal of …, 2008 - rupress.org
Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC),
gastric carcinoma (GC), and other malignancies. EBV is the first human virus found to …